Erratum: Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis
نویسندگان
چکیده
Lucy A. Weinert, Roy R. Chaudhuri, Jinhong Wang, Sarah E. Peters, Jukka Corander, Thibaut Jombart, Abiyad Baig, Kate J. Howell, Minna Vehkala, Niko Välimäki, David Harris, Tran Thi Bich Chieu, Nguyen Van Vinh Chau, James Campbell, Constance Schultsz, Julian Parkhill, Stephen D. Bentley, Paul R. Langford, Andrew N. Rycroft, Brendan W. Wren, Jeremy Farrar, Stephen Baker, Ngo Thi Hoa, Matthew T.G. Holden, Alexander W. Tucker, Duncan J. Maskell & BRaDP1T Consortium
منابع مشابه
Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis
Streptococcus suis causes disease in pigs worldwide and is increasingly implicated in zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S. suis, we study the genomes of 375 isolates with detailed clinical phenotypes from pigs and humans from the United Kingdom and Vietnam. Here, we show that isolates associated with disease contain substantially fewer g...
متن کاملAn emerging zoonotic clone in the Netherlands provides clues to virulence and zoonotic potential of Streptococcus suis
Streptococcus suis is a zoonotic swine pathogen and a major public health concern in Asia, where it emerged as an important cause of bacterial meningitis in adults. While associated with food-borne transmission in Asia, zoonotic S. suis infections are mainly occupational hazards elsewhere. To identify genomic differences that can explain zoonotic potential, we compared whole genomes of 98 S. su...
متن کاملStreptococcus suis, an Emerging Drug-Resistant Animal and Human Pathogen
Streptococcus suis, a major porcine pathogen, has been receiving growing attention not only for its role in severe and increasingly reported infections in humans, but also for its involvement in drug resistance. Recent studies and the analysis of sequenced genomes have been providing important insights into the S. suis resistome, and have resulted in the identification of resistance determinant...
متن کاملRapid Evolution of Virulence and Drug Resistance in the Emerging Zoonotic Pathogen Streptococcus suis
BACKGROUND Streptococcus suis is a zoonotic pathogen that infects pigs and can occasionally cause serious infections in humans. S. suis infections occur sporadically in human Europe and North America, but a recent major outbreak has been described in China with high levels of mortality. The mechanisms of S. suis pathogenesis in humans and pigs are poorly understood. METHODOLOGY/PRINCIPAL FIND...
متن کاملStreptococcal Adhesin P (SadP) contributes to Streptococcus suis adhesion to the human intestinal epithelium
BACKGROUND Streptococcus suis is a zoonotic pathogen, causing meningitis and septicemia. We previously demonstrated that the gastrointestinal tract (GIT) is an entry site for zoonotic S. suis infection. Here we studied the contribution of Streptococcal adhesin Protein (SadP) to host-pathogen interaction at GIT level. METHODS SadP expression in presence of Intestinal Epithelial Cells (IEC) was...
متن کامل